The Genome targeting and editing platform aims to provide experimental and technical expertise to researchers interested in performing targeted or genome-wide screens and the generation of cellular and animal models using the CRISPR-Cas9 system. The platform will work directly to:

 

• create novel reporter systems

• optimize relevant strategies

• design, amplify and package sgRNA libraires

• assist in reagent and vector generation and creation

• library sequencing preparation and data analysis

• incorporate and develop new advances and technologies in the field

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PROPOSED SERVICES

We are currently hosting several mouse and human CRISPR inhibition and activation libraries for genome-wide screening:

 

• Dolomiti_setA (murine inhibition)

• Dolcetto_setA (human inhibition)

• Coprano_setA (murine activation)

• Calabrese_setA (human activation)

• Human_v2_Inhibition_top5

• Human_v2-Activation_top5

• Mouse_v2_Inhibition_top5

 

In addition, the platform has a wide variety of targeting constructs to assist in creating custom cellular and animal models (working directly with the Transgenesis Platform).